Research Status of Immune Microenvironment in Triple Negative Breast Cancer

Triple negative breast cancer (TNBC) is the most aggressive subtype of cancer, with limited treatment options and high rates recurrence metastasis due to lack specific therapeutic targets. The incidence bone metastases brain also high. They are more likely relapse have a poor long-term prognosis. tumor microenvironment (TME) consists cells, variety mesenchymal cells an extracellular matrix, which together induce proliferation, stimulate angiogenesis, inhibit cell apoptosis regulate immune system, thereby blocking TNBC’s anti-tumor response promote progression metastasis. TNBC has unique TME, TME may be potential target for TNBC. However, overall pattern phenotypes remains unknown. Because dense crosstalk, it reasonable consider them as whole. This article will review characteristics latest progress immunotherapy.